Dynamics of viral shedding during ancestral or Omicron BA.1 SARS-CoV-2 infection and enhancement of pre-existing immunity during breakthrough infectionsArticle Published on 2022-12-012022-11-15 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] addition Anti-RBD IgG antibody Breakthrough infection Cell cellular immunity cellular response circulating Delta Diagnosis Dynamics exhibited faster greater HCW HCWs healthcare worker humoral IFN-γ Immunity Infection infectiousness investigated isolates median neutralization capacity neutralizing antibody titre normalized omicron pandemic positive pre-existing immunity proportion reported RT-qPCR SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 isolates SARS-CoV-2 peptides SARS-CoV-2 variants symptom onset Vaccine vaccine-immunity variant viral clearance viral culture Viral load viral loads viral shedding Viral shedding. [DOI] 10.1080/22221751.2022.2122578 PMC 바로가기
SARS-CoV-2 antibody profile of naturally infected and vaccinated individuals detected using qualitative, semi-quantitative and multiplex immunoassaysArticle Published on 2022-12-012022-11-15 Journal: Diagnostic microbiology and infectious disease [Category] COVID19(2023년), SARS, 진단, 치료기술, 치료제, [키워드] anti-N antibody anti-RBD anti-S2 Anti-spike antibodies antibody Antibody profile Antigen average Cohort demonstrated exhibited HCW healthcare worker IgG immune immunoassay individual Infection infection cohort mRNA vaccines multiplex natural infection Patient positive produced reactivity SARS-CoV-2 SARS-CoV-2 antibody semi-quantitative Support target vaccinated individual vaccination vaccination. [DOI] 10.1016/j.diagmicrobio.2022.115803 PMC 바로가기
SARS-CoV-2 fusion-inhibitory lipopeptides maintain high potency against divergent variants of concern including OmicronSARS-CoV-2 융합 억제 리포펩티드는 오미크론을 포함한 다양한 관심 변종에 대해 높은 효능을 유지합니다Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] activity Alpha antiviral activity Beta broad-spectrum antiviral broad-spectrum antivirals Cell Cell fusion cell-cell fusion combating COVID-19 pandemic D614G Delta drugs effective vaccine Effective vaccines exhibited FIVE fusion inhibitor Gamma Impact Infection inhibiting inhibitor inhibitors Lambda lipopeptide maintain mutant omicron Omicron variant other variant other variants outbreak pseudovirus pseudovirus pseudovirus infection pseudoviruses reduced S protein S proteins SARS-CoV-2 significantly the S protein therapeutic variant variants variants of concern variants of concern. VoC VOCs wild-type WT virus [DOI] 10.1080/22221751.2022.2098060 PMC 바로가기 [Article Type] Article
mRNA based vaccines provide broad protection against different SARS-CoV-2 variants of concernmRNA 기반 백신은 우려되는 다양한 SARS-CoV-2 변이체에 대한 광범위한 보호를 제공합니다.Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] Beta Clinical use COVID-19 COVID-19 mRNA vaccine COVID-19 mRNA vaccines cross-reactive Delta described exhibited Heterologous homologous immunogenicity indicated Messenger RNA mRNA mRNA vaccine mRNA-based vaccine mRNA-based vaccines nCoV neutralization omicron overcome pandemic of COVID-19 SARS-CoV-2 variant SARS-CoV-2 variants Vaccine vaccine. variants [DOI] 10.1080/22221751.2022.2081616 PMC 바로가기 [Article Type] Article
Differential transcriptomic landscapes of multiple organs from SARS-CoV-2 early infected rhesus macaquesSARS-CoV-2 초기 감염된 붉은털 원숭이의 여러 기관의 차등 전사체 풍경Article Published on 2022-12-012022-09-11 Journal: Protein & Cell [Category] COVID19(2023년), SARS, 유전자 메커니즘, 진단, [키워드] accompanied analyzed Angiogenesis cause Central nervous system cerebral cortex changes in clinical complications clinical manifestation clinical manifestations CNS Coagulation controls drastic dysregulation early infection elevated Encephalitis evidenced examined exhibited expression expressions Factor fibrosis function Genes hyperinflammatory state immune response immune responses infected with SARS-CoV-2 Infection Inflammation inflammation response Inflammatory factor inflammatory factors mechanism multiple organ neuropilin 1 NRP1 organs positive positive feedback post infection provide receptor rhesus rhesus macaque right ventricle SARS-CoV-2 SARS-COV-2 infection significantly tissue tissues transcriptomic transcriptomic alteration Transmission up-regulated upregulation Viral viral encephalitis viral encephalitis. [DOI] 10.1007/s13238-022-00915-5 PMC 바로가기 [Article Type] Article
The inhibitory activity of methoxyl flavonoids derived from Inula britannica flowers on SARS-CoV-2 3CLproArticle Published on 2022-12-012022-11-15 Journal: International journal of biological macromolecules [Category] COVID19(2023년), SARS, 치료제, [키워드] 3CLpro concentrations coronavirus effective effort exhibited flavonoid HCoV-OC43 Hydrogen bond identify inhibited inhibitor inhibitory activity Inula britannica key amino acid Methoxyl flavonoids molecular simulations natural antiviral nuclear proliferation SARS- CoV-2 SARS-CoV-2 SARS-CoV-2. Structure suppressed [DOI] 10.1016/j.ijbiomac.2022.10.008 PMC 바로가기
Comparable antigen-specific T cell responses in vaccinees with diverse humoral immune responses after the primary and booster BBIBP-CorV vaccinationArticle Published on 2022-12-012022-11-15 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 진단, 치료기술, 치료제, [키워드] Anti-spike Antibody Response B cell B cell responses BBIBP-CorV booster booster vaccination CD4 CD8 comparable COVID-19 COVID-19 vaccines de novo demonstrated detectable dramatic increase Epidemic exhibited Features humoral immune response Humoral immunity humoral responses interferon-γ Neutralizing antibodies omicron remained S protein SARS-CoV-2 SARS-COV-2 infection serotype Severe case Shanghai significantly T cell T cell response T cell responses T cell responses. Th1 cytokine vaccination vaccinee vaccinees wild type [DOI] 10.1080/22221751.2022.2130101 PMC 바로가기
Neutralizing response elicited by homologous and heterologous prime booster vaccination against ancestral SARS-CoV-2 B.1, P.1, C.37 and B.1.617.2 variantsArticle Published on 2022-11-082022-11-15 Journal: Vaccine [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] analysed B.1 B.1.617.2 BBIBP-CorV booster vaccination ChAdOx1-S Combination country COVID-19 elicited exhibited Gam-COVID-Vac greater Heterologous heterologous vaccination homologous immunized information mRNA-1273 mRNA-1273 vaccines Neutralizing Neutralizing antibodies non-replicative P.1 participant percentage Population protocol protocols provided SARS-CoV-2 second dose serum shortage significantly significantly lower vaccination Vaccination strategies Vaccination strategy Vaccine variant variants of concern. viral vector-based [DOI] 10.1016/j.vaccine.2022.10.021 PMC 바로가기
Characterization and immunogenicity of SARS-CoV-2 spike proteins with varied glycosylationArticle Published on 2022-11-082022-11-15 Journal: Vaccine [Category] SARS, 진단, [키워드] 293 cells 293F cell acute respiratory syndrome addition binding caused Cell changed characterization convalescent sera coronavirus Coronavirus disease-19 COVID-19 Critical discrepancy effective Efficacy elicited exhibited expression globe glycosylated glycosylation glycosylation pattern homogeneity host cells IgG immunization immunogenicity insect cell mammalian cells mice Neutralizing antibody response neutralizing antibody titre pandemic Protein Proteins provide reactivity Receptor binding regimen robust S protein S-2P SARS-CoV-2 SARS-CoV-2 spike protein spike Spike. the S protein thermal stability Vaccine Vaccine design Variation virus virus entry while [DOI] 10.1016/j.vaccine.2022.09.057 PMC 바로가기
Intrinsic host susceptibility among multiple species to intranasal SARS-CoV-2 identifies diverse virological, biodistribution and pathological outcomesArticle Published on 2022-11-042022-11-15 Journal: Scientific Reports [Category] SARS, 진단, [키워드] administration airway analysed association Asymptomatic atraumatic biodistribution cardiovascular systems Cell consequence cynomolgus macaque cynomolgus macaques Disrupted exhibit exhibited hamster Host host susceptibility hosts identify Infection Infectious virus intranasal Lower respiratory tract lung Lung pathology methodology Microscopy Mild molecular morphology New World NHP non-human primate organelle outcome outcomes Pathogenesis pathological outcome pathology pathophysiological Post-infection Replication representing SARS-CoV-2 SARS-COV-2 infection susceptible ultrastructure Virological virus virus particle [DOI] 10.1038/s41598-022-23339-x PMC 바로가기